Cysteine is a limiting factor for glioma proliferation and survival
M. Larion, V. Ruiz-Rodado, T. Dowdy, A. Lita, T. Kramp, M. Zhang, J. Jung, A. Dios-Esponera, C. C. Herold-Mende, K. Camphausen, M. R. Gilbert
This study shows that glioma cells depend on exogenous cysteine/cystine, and dietary restriction extends survival in a mouse model, though tumors can later compensate by synthesizing glutathione.
bioRxiv · Jan 8, 2021Cancer Biology