T. Dowdy

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors

This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.

Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.

DMT1 contributes to MF- 438 - mediated inhibition of glioma cells

The paper shows MF-438 inhibits glioma growth through both SCD1-dependent lipid metabolism disruption and SCD1-independent DMT1 suppression.

Resolving Challenges in Detection and Quantification of D-2-hydroxyglutarate and L-2-hydroxyglutarate via LC/MS

This paper develops a high-throughput HR-QTOF-LC/MS method to accurately quantify D-2HG and L-2HG enantiomers, enabling better understanding of their roles in disease.

Cysteine is a limiting factor for glioma proliferation and survival

This study shows that glioma cells depend on exogenous cysteine/cystine, and dietary restriction extends survival in a mouse model, though tumors can later compensate by synthesizing glutathione.

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids

This paper identifies lipid imbalances caused by IDH1 mutations that lead to organelle dysfunction, with therapeutic implications for glioma treatment.