M. R. Gilbert

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

"Tumor Treating Fields" delivered via electromagnetic induction have varied effects across glioma cell lines and electric field amplitudes

This study applies electromagnetic fields to glioma cell lines and finds variable effects on proliferation and gene expression, contradicting previous in vitro findings of consistent anti-proliferative effects.

MAIT cells have a negative impact on glioblastoma

The paper identifies MAIT cells as immunosuppressive in glioblastoma, correlating their presence with poor patient survival and immune suppressive gene upregulation.

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial ependymoma

The paper identifies a novel subset of supratentorial ependymomas in children characterized by recurrent PLAGL1 fusions and distinct molecular features.

Cysteine is a limiting factor for glioma proliferation and survival

This study shows that glioma cells depend on exogenous cysteine/cystine, and dietary restriction extends survival in a mouse model, though tumors can later compensate by synthesizing glutathione.

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids

This paper identifies lipid imbalances caused by IDH1 mutations that lead to organelle dysfunction, with therapeutic implications for glioma treatment.

Whole exome precision oncology targeting synthetic lethal vulnerabilities across the tumor transcriptome

This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.