Author

T. L. Tootle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Organism:Drosophila· 5 Approach:experimental assay· 4 Research Focus:development & morphogenesis· 2 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

M. C. Lamb· 4 shared A. J. Spracklen· 1 shared A. V. Tivanski· 1 shared C. M. Groen· 1 shared C. P. Kaluarachchi· 1 shared E. F. Fox· 1 shared J. M. Thomalla· 1 shared K. K. Anliker· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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4 shared papersCell Biology

M. C. Lamb

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Author profile →

5 papers

Recent·Most cited

Adipose triglyceride lipase promotes prostaglandin-dependent actin remodeling by regulating substrate release from lipid droplets

M. S. Giedt, J. M. Thomalla, M. R. Johnson, Z. W. Lai, T. L. Tootle, M. A. Welte

This study shows that ATGL regulates actin remodeling in Drosophila oogenesis by releasing arachidonic acid from lipid droplets to drive prostaglandin synthesis, essential for follicle development and fertility.

bioRxiv · Aug 2, 2021Cell Biology

Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

M. C. Lamb, C. P. Kaluarachchi, T. I. Lansakara, Y. Lan, A. V. Tivanski, T. L. Tootle

The paper identifies Fascin as a regulator of Myosin activity in Drosophila border cells, showing it controls substrate stiffness to enhance migration.

bioRxiv · Apr 27, 2021Cell Biology

Prostaglandins regulate invasive, collective border cell migration

E. F. Fox, M. C. Lamb, S. Q. Melletine, T. L. Tootle

The paper shows that prostaglandins regulate integrin localization and Fascin to control collective border cell migration in Drosophila.

bioRxiv · Oct 28, 2019Cell Biology

Fascin regulates protrusions and delamination to promote invasive, collective cell migration in vivo.

M. C. Lamb, K. K. Anliker, T. L. Tootle

This study shows Fascin regulates protrusions and delamination in Drosophila border cell migration through both actin-dependent and -independent mechanisms, with implications for cancer metastasis.

bioRxiv · Aug 13, 2019Cell Biology

Pharmaco-genetic screen to uncover actin regulators targeted by prostaglandins during Drosophila oogenesis

A. J. Spracklen, M. C. Lamb, C. M. Groen, T. L. Tootle

The paper performs a pharmaco-genetic screen in Drosophila oogenesis to identify actin regulators affected by prostaglandins, finding enhancers like Enabled and Capping protein.

bioRxiv · Aug 1, 2019Cell Biology