Colonic epithelial adaptation to EGFR-independent growth induces induces chromosomal instability and is accelerated by prior injury
T. Chen, M. Zeineldin, B. Johnson, Y. Dong, A. Narkar, T. Li, J. Zhu, R. Li, T. Larman
This study shows that colonic epithelial cells adapt to EGFR-independent growth, leading to chromosomal instability and accelerated by prior injury, without introducing cancer driver mutations.
bioRxiv · Feb 2, 2021Cancer Biology