Differential effects of aneuploidy on growth and differentiation in human intestinal stem cells
B. A. Johnson, A. Z. Liu, T. Bi, Y. Dong, T. Li, D. Zhou, A. Narkar, Y. Wu, S. Sun, T. C. Larman, J. Zhu, R. Li
This study investigates how different types of aneuploidy affect growth and differentiation in human intestinal stem cells, finding that complex aneuploidy triggers p53 activation and cell-cycle arrest, while simple aneuploidy allows continued proliferation and impaired differentiation.
bioRxiv · Sep 23, 2023 · PreprintCell Biology