Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened
Y. R. Yang, L. E. McCoy, M. J. van Gils, R. Andrabi, H. L. Turner, M. Yuan, C. Cottrell, G. Ozorowski, J. E. Voss, M. Pauthner, T. M. Polveroni, T. Messmer, I. A. Wilson, R. W. Sanders, D. R. Burton, A. B. Ward
This study shows that immunization with B41 and BG505 SOSIP trimer immunogens in rabbits induces distinct autologous neutralizing antibody lineages targeting overlapping glycan hole epitopes, but broadening reactivity remains challenging.
bioRxiv · Nov 1, 2019Immunology