T. Messmer

Optimisation of cell fate determination for cultured muscle differentiation

This study identifies key pathways for improving muscle cell differentiation in vitro, achieving near-complete fusion and enhanced muscle protein production in bioartificial constructs.

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple epitopes

The paper identifies two broadly neutralizing antibodies against coronaviruses by screening B cell repertoires, showing they target different epitopes and offer protection against variants.

Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies

The paper structures and characterizes Lassa virus glycoproteins from multiple lineages and identifies neutralizing antibodies that target conserved epitopes.

Single-cell analysis of bovine muscle-derived cell types for cultured meat production

This study uses single-cell RNA sequencing to characterize bovine muscle cell types and develop protocols for their purification and proliferation in cultured meat production.

Comparative analysis of cattle breeds as satellite cell donors for cultured beef

The paper compares SC proliferation and differentiation across cattle breeds to identify optimal donors for cultured beef production.

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

The paper identifies monoclonal antibodies from rabbits that bind an epitope overlapping the N332 glycan supersite but not the glycan hole, suggesting strain-specific responses may interfere with broadly neutralizing antibodies.

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

This study shows that immunization with B41 and BG505 SOSIP trimer immunogens in rabbits induces distinct autologous neutralizing antibody lineages targeting overlapping glycan hole epitopes, but broadening reactivity remains challenging.