Author

Y. R. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Organism:human· 1

Frequent Co-Authors

A. B. Ward· 3 shared D. R. Burton· 2 shared H. R. Perrett· 2 shared R. W. Sanders· 2 shared A. Antanasijevic· 1 shared A. B. McDermott· 1 shared A. Chopde· 1 shared A. J. Rodriguez· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

A. B. Ward

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Author profile →

4 papers

Recent·Most cited

Enhanced Antibody Response to the Conformational Non-RBD Region via DNA Prime-Protein Boost Elicits Broad Cross-Neutralization Against SARS-CoV-2 Variants

Y.-F. Ma, K. Chen, B. Xie, J. Zhu, X. He, C. Chen, Y. R. Yang, Y. Liu

This study shows that DNA prime-protein boost elicits enhanced antibodies against non-RBD regions of SARS-CoV-2, improving cross-neutralization against variants in mice.

bioRxiv · Feb 4, 2024 · PreprintImmunology

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

Y. R. Yang, J. Han, H. R. Perrett, S. T. Richey, A. M. Jackson, A. J. Rodriguez, R. A. Gillespie, S. O'Connell, J. E. Raab, L. Y. Cominsky, A. Chopde, M. Kanekiyo, K. V. Houser, G. L. Chen, A. B. McDermott, , A. B. Ward

This study examines how prior H2 influenza exposure influences polyclonal antibody responses to H2N2 vaccination, showing differences in epitope targeting between H2-exposed and H2-naive individuals.

bioRxiv · Aug 23, 2023Immunology

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

A. Antanasijevic, L. M. Sewall, C. A. Cottrell, D. G. Carnathan, L. E. Jimenez, J. T. Ngo, J. B. Silverman, B. Groschel, E. Georgeson, J. Bhiman, R. Bastidas, C. LaBranche, J. D. Allen, J. Copps, H. R. Perrett, , A. B. Ward

The paper uses cryoEM to analyze polyclonal antibody responses to HIV Env immunogens in rhesus macaques, revealing structural differences in antibody binding and immunogenicity of engineered mutations and glycan sites.

bioRxiv · Jan 28, 2021Immunology

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

Y. R. Yang, L. E. McCoy, M. J. van Gils, R. Andrabi, H. L. Turner, M. Yuan, C. Cottrell, G. Ozorowski, J. E. Voss, M. Pauthner, T. M. Polveroni, T. Messmer, I. A. Wilson, R. W. Sanders, D. R. Burton, A. B. Ward

This study shows that immunization with B41 and BG505 SOSIP trimer immunogens in rabbits induces distinct autologous neutralizing antibody lineages targeting overlapping glycan hole epitopes, but broadening reactivity remains challenging.

bioRxiv · Nov 1, 2019Immunology