The monothiol glutaredoxin Grx4 interacts with the Cryptococcus iron regulator Cir1 and regulates iron homeostasis and virulence in the Cryptococcus neoformans
R. Attarian, G. Hu, M. Caza, E. Sanchez-Leon, D. Croll, E. Do, H. Bach, T. Missall, J. Lodge, W. H. Jung, J. W. Kronstad
This study identifies Grx4 as a binding partner of Cir1 in Cryptococcus neoformans, showing that Grx4 regulates iron homeostasis and virulence through its interaction with Cir1.
bioRxiv · Jun 28, 2018Microbiology