G. Hu

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Glutathione metabolism impacts fungal virulence by modulating the redox environment

This study shows that glutathione metabolism in Cryptococcus neoformans affects virulence by modulating redox processes and melanin production in a murine infection model.

Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

This study shows that artesunate, EDTA, and colistin work together to fight Salmonella strains resistant to colistin, by damaging cell membranes and inhibiting MCR-1.

The interplay between electron transport chain function and iron regulatory factors influences melanin formation in Cryptococcus neoformans

This paper investigates how mitochondrial electron transport chain function and iron regulatory factors influence melanin formation in Cryptococcus neoformans, revealing a link between mitochondrial dysfunction, redox homeostasis, and virulence.

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

Self-inspired learning to denoise for live-cell super-resolution microscopy

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

Endogenous glucocorticoids are required for normal macrophage activation and gastric Helicobacter pylori immunity

This study shows that glucocorticoids are necessary for proper macrophage activation and immune response to Helicobacter pylori in the stomach.

Exploring information exchange between Thesium chinense and its host Prunella vulgaris through joint transcriptomic and metabolomic analysis

This study identifies 5 transferred metabolites and 668 mobile genes between Thesium chinense and its host Prunella vulgaris, revealing information exchange critical for haustoria formation and parasitism.

Bosutinib stimulates macrophage survival, phagocytosis and intracellular killing of bacteria

This paper shows bosutinib enhances macrophage phagocytosis and bacterial killing, reducing infection in mice.

Continuity of Mitochondrial Budding: Insights from BS-C-1 Cells by in-situ Cryo-Electron Tomography

The paper uses in-situ Cryo-ET to study mitochondrial budding in BS-C-1 cells, finding no Drp1 or ER involvement and identifying new mitochondrial-vesicle interactions.

Genetic Screen Identified Prmt5 as a Neuroprotection Target against Cerebral Ischemia

This study identifies Prmt5 as a negative regulator of neuronal survival during cerebral ischemia and shows that its inhibition protects against neuronal death in a mouse model.

Characterization of extracellular vesicles isolated from Sorghum bicolor reveals a conservation between monocot and eudicot extracellular vesicle proteomes

This study isolates and characterizes extracellular vesicles from Sorghum bicolor, showing partial conservation of EV proteomes with Arabidopsis.

Coronary Artery Disease Risk Gene PRDM16 is Preferentially Expressed in Vascular Smooth Muscle Cells and a Potential Novel Regulator of Smooth Muscle Homeostasis

This study identifies PRDM16 as a novel regulator of vascular smooth muscle cell homeostasis, showing its preferential expression in contractile VSMCs and its role in modulating CAD risk genes.

Enhanced niche colonisation and competition during bacterial adaptation to a fungus

This study evolves Bacillus subtilis in co-culture with Aspergillus niger, finding enhanced surfactin production and surface spreading that inhibit fungal growth.

Parallel genetic adaptation of Bacillus subtilis to different plant species

This study shows Bacillus subtilis adapts genetically to different plant hosts and alternating host regimes, revealing both parallel and species-specific evolutionary patterns.

Magnesium ions mediate ligand binding and conformational transition of the SAM/SAH riboswitch

This study shows Mg2+ ions stabilize the SAM/SAH riboswitch structure and influence ligand binding and conformational changes through inner and outer-shell coordination.

Enhancing detectable fluorescence fluctuation for high-throughput and four-dimensional live-cell super-resolution imaging

This paper introduces SACD, a super-resolution imaging method that reduces acquisition time and improves resolution, enabling high-throughput and 4D live-cell imaging.

Species and condition shape the mutational spectrum in experimentally evolved biofilms

This study compares mutational spectra in biofilms of two Bacillus species under abiotic and biotic conditions, finding that smaller population sizes and biotic environments lead to higher mutation rates and diversity.

Mitoxantrone Targets Both Host and Bacteria to Overcome Vancomycin Resistance in Enterococcus faecalis

Mitoxantrone synergizes with vancomycin against vancomycin-resistant Enterococcus faecalis by direct antibiotic activity and enhancing host macrophage recruitment and bactericidal activity.

EDoF-Miniscope: pupil engineering for extended depth-of-field imaging in a fluorescence miniscope

The paper introduces EDoF-Miniscope, a fluorescence miniscope with extended depth-of-field imaging, achieving 2.8X depth extension and high-contrast signals in mouse brain samples.

The LncRNA Carmn is a Critical Regulator for Gastrointestinal Smooth Muscle Contractile Function and Motility

This study identifies Carmn, a SMC-specific lncRNA, as critical for maintaining GI smooth muscle contractile function and motility, with loss of function leading to impaired contractility and pseudo-obstruction.

Dissecting Mutational Allosteric Effects in Alkaline Phosphatases Associated with Different Hypophosphatasia Phenotypes: An Integrative Computational Investigation

This paper uses computational methods to analyze ALPL mutations in Hypophosphatasia, finding that severe mutations significantly affect allosteric communications and protein stability.

Adeno-associated Virus Receptor-binding: Flexible Domains and Alternative Conformations through cryo-Electron Tomography of AAV2 and AAV5 complexes

This paper uses cryo-ET to reveal flexible domains and alternative conformations of AAV2 and AAV5 receptor complexes, showing structural complexity relevant to viral entry and gene therapy.

Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor

This study cultivates Akkermansia muciniphila in a dynamic bionic intestinal reactor with different media, finding higher biomass and specific metabolites under human mucin conditions.

Dual domestication, diversity, and differential introgression in Old World cotton diploids

This study investigates the domestication and genetic diversity of two diploid cotton species, confirming independent domestication and identifying patterns of introgression and chromosomal variability.

Limited variation between SARS-CoV-2-infected individuals in domain specificity and relative potency of the antibody response against the spike glycoprotein

The paper analyzes antibody responses in SARS-CoV-2-infected individuals, finding limited variation in domain specificity and relative neutralization potency across subjects.

Binding Free energy Decomposition and Multiple Unbinding Paths of Buried Ligands in a PreQ1 Riboswitch

This study uses molecular dynamics simulations to analyze binding free energy and unbinding paths of ligands in a PreQ1 riboswitch, identifying key nucleotide contributions and structural changes.

Experimental evolution of Bacillus subtilis on Arabidopsis thaliana roots reveals fast adaptation and improved root colonization in the presence of soil microbes

This study shows Bacillus subtilis rapidly adapts to Arabidopsis roots, improving colonization and biofilm formation, but with reduced motility and fitness costs in non-selective environments.

Prenatal cadmium exposure alters proliferation in mouse CD4+ T cells via LncRNA Snhg7

This study shows prenatal cadmium exposure increases lncSnhg7 and GALNT7 in mouse CD4+ T cells, enhancing proliferation through miR-34a regulation.

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice

This study shows that non-neutralizing antibodies targeting HIV-1 envelope regions reduce mucosal infection and virus burden in humanized mice through Fc-mediated effector functions.