Preponderant Myosin Super-Relaxed State In Skeletal Muscle From Endurance Athletes
C. T. A. Lewis, L. Tabrizian, J. Nielsen, J. Laitila, T. N. Beck, P. Aagaard, R. Hokken, S. Laugesen, A. Ingersen, J. L. Andersen, C. Soendenbroe, J. W. Helge, F. Dela, S. Larsen, R. E. Sahl, , J. Ochala
This study shows that endurance training increases the super-relaxed state of myosin in skeletal muscle, reducing ATP turnover and diminishing the effect of the drug Mavacamten.
bioRxiv · Sep 23, 2022 · PreprintPhysiology