Author

J. Laitila

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:deep learning· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

J. Ochala· 4 shared C. T. A. Lewis· 2 shared E. Zanoteli· 2 shared R. E. Sahl· 2 shared A. Ingersen· 1 shared A. L. Hessel· 1 shared A. S. Deshmukh· 1 shared A. V. Goropashnaya· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersPhysiology

J. Ochala

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Myosin ATPase inhibition fails to rescue the metabolically dysregulated proteome of nebulin-deficient muscle

J. Laitila, R. Seaborne, N. Ranu, J. Kolb, C. Wallgren-Pettersson, N. Witting, J. Vissing, J. J. Vilchez, E. Zanoteli, J. Palmio, S. Huovinen, H. Granzier, J. Ochala

This study tests Mavacamten's ability to rescue metabolic dysregulation in nebulin-deficient muscle, finding it effective in vitro but ineffective in vivo for reversing the proteome changes.

bioRxiv · May 7, 2024Physiology

Remodelling of Skeletal Muscle Myosin Metabolic States in Hibernating Mammals

C. T. A. Lewis, E. G. Melhedegaard, M. M. Ognjanovic, M. S. Olsen, J. Laitila, R. A. E. Seaborne, M. N. Gronset, C. Zhang, H. Iwamoto, A. L. Hessel, M. N. Kuehn, C. Merino, N. Amigo, O. Frobert, S. Giroud, , J. Ochala

This study examines changes in skeletal muscle myosin metabolic states during hibernation in different mammals, finding reduced ATP consumption and potential mechanisms for energy conservation.

bioRxiv · Nov 14, 2023 · PreprintPhysiology

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains

R. Moreno-Justicia, T. Van der Stede, B. Stocks, J. Laitila, R. A. Seaborne, A. Van de Loock, E. Lievens, D. Samodova, L. Marin-Arraiza, O. Dmytriyeva, R. Browaeys, K. Van Vossel, L. Moesgaard, N. Yigit, J. Anckaert, , A. S. Deshmukh

This study identifies sources of skeletal muscle fiber heterogeneity beyond myosin heavy chains using transcriptomic and proteomic data from human muscle fibers.

bioRxiv · Sep 7, 2023Physiology

Preponderant Myosin Super-Relaxed State In Skeletal Muscle From Endurance Athletes

C. T. A. Lewis, L. Tabrizian, J. Nielsen, J. Laitila, T. N. Beck, P. Aagaard, R. Hokken, S. Laugesen, A. Ingersen, J. L. Andersen, C. Soendenbroe, J. W. Helge, F. Dela, S. Larsen, R. E. Sahl, , J. Ochala

This study shows that endurance training increases the super-relaxed state of myosin in skeletal muscle, reducing ATP turnover and diminishing the effect of the drug Mavacamten.

bioRxiv · Sep 23, 2022 · PreprintPhysiology