S. Larsen

Spatial and network principles behind neural generation of locomotion

The paper proposes spatial and network principles for locomotion generation in the spinal cord using a mouse model and integrates single-cell RNA sequencing with spatial transcriptomics.

Dysregulated Skeletal Muscle Myosin Super-relaxation and Energetics in Type II Diabetes

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

Housing temperature dictates the systemic and tissue specific molecular responses to cancer in mice

This study shows that housing temperature affects molecular and systemic responses to cancer in mice, influencing metabolic adaptations and cytokine levels.

Metagenomics untangles metabolic adaptations of Antarctic endolithic 1 bacteria at the fringe of habitability

The paper analyzes metagenomic data from Antarctic endolithic microbiomes to identify metabolic strategies supporting life at extreme environmental limits.

A transmission chain linking Mycobacterium ulcerans with Aedes notoscriptus mosquitoes, possums and human Buruli ulcer cases in southeastern Australia

The paper investigates the transmission chain of Mycobacterium ulcerans between mosquitoes, possums, and humans in southeastern Australia, finding a significant association between M. ulcerans and Aedes notoscriptus mosquitoes.

The myocyte Nfe2l1-ubiquitin-proteasome system controls muscle fiber type and obesity-induced insulin resistance

This study shows that Nfe2l1 regulates skeletal muscle proteostasis and function, with its loss causing muscle fiber type switching and insulin resistance in high-fat diet conditions.

Peripheral blood mononuclear cells exhibit increased mitochondrial respiration after adjuvant chemo- and radiotherapy for early breast cancer

This study shows that mitochondrial respiration in PBMCs increases after adjuvant chemo- and radiotherapy in postmenopausal EBC patients, possibly due to changes in PBMC subpopulations or mitochondrial content.

Preponderant Myosin Super-Relaxed State In Skeletal Muscle From Endurance Athletes

This study shows that endurance training increases the super-relaxed state of myosin in skeletal muscle, reducing ATP turnover and diminishing the effect of the drug Mavacamten.

Choice of medium affects PBMC quantification, cell size, and downstream respiratory analysis

This study examines how different media affect PBMC quantification, size, and respiratory analysis, finding significant variations in O2 flux and cell size across media types.

Multidimensional natal isotopic niches reflect migratory patterns in birds

The paper uses isotopic analysis of bird feathers to study migratory patterns and ecological niches across different bird species.

rasterdiv - an Information Theory tailored R package for measuring ecosystem heterogeneity from space: to the origin and back

The paper introduces an R package called rasterdiv for measuring ecosystem heterogeneity using remotely sensed data and demonstrates its application in revealing hidden heterogeneity patterns.

Flooding and hydrologic connectivity modulate community assembly in a dynamic river-floodplain ecosystem

This study examines how flooding and hydrologic connectivity affect community assembly in a river-floodplain ecosystem, finding that deterministic processes dominate during stable periods but stochastic processes increase after flooding.

WFD ecological status indicator shows poor correlation with flow parameters in a large Alpine catchment

The paper evaluates the relationship between the Star_ICMi ecological indicator and hydrologic parameters in Alpine rivers, finding weak correlations and identifying key flow parameters that limit macroinvertebrate communities.

Stress response of Chironomus riparius to changes in water temperature and oxygen concentration in a lowland stream

This study examines how Chironomus riparius larvae respond to short-term changes in water temperature and oxygen concentration by measuring HSP70 and Hb levels, finding HSP70 responds to temperature while Hb correlates with oxygen.