J. Nielsen

Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells

This study shows proinflammatory cytokines suppress NMD activity in β-cells by downregulating UPF3B, leading to increased alternative splicing and ECM-related gene expression, which contributes to β-cell dysfunction.

Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

This study shows that the Bri2 BRICHOS domain inhibits α-synuclein oligomer formation and toxicity by suppressing secondary nucleation and binding oligomers, suggesting its potential as a therapeutic target for Parkinson's disease.

Differential utilisation of subcellular skeletal muscle glycogen pools: A comparative analysis between 1 and 15 minutes of maximal exercise

This study compares glycogen pool utilisation during 1- and 15-minute maximal exercises and examines the effects of low carbohydrate intake on glycogen storage and usage.

Biosensor-Assisted Laboratory Evolution of Malonyl-CoA production in Saccharomyces cerevisiae

This study develops a CRISPR-dCas9 platform to enhance malonyl-CoA production in yeast through laboratory evolution.

Increased mitochondrial surface area and cristae density in the skeletal muscle of strength athletes

This study examines mitochondrial structural changes in strength athletes compared to untrained controls, finding increased cristae density and surface-to-volume ratio, along with transcriptomic evidence of mitochondrial biogenesis and stress responses.

Drug repurposing screens identifies compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions

Preponderant Myosin Super-Relaxed State In Skeletal Muscle From Endurance Athletes

This study shows that endurance training increases the super-relaxed state of myosin in skeletal muscle, reducing ATP turnover and diminishing the effect of the drug Mavacamten.

Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

The paper models metabolic interactions in the tumor microenvironment and finds that enzymatic capacity limits, not collaboration, drive cancer cell metabolism and growth.

Polarized α-synuclein trafficking and transcytosis across Brain Endothelial Cells via Rab7-decorated carriers

This study identifies Rab7-decorated carriers mediating polarized transcytosis of monomeric α-synuclein across brain endothelial cells, suggesting Rab7 as a therapeutic target for Parkinson's disease.

Specific ATPases drive compartmentalized glycogen utilization in rat skeletal muscle

The paper shows that three ATPases in rat skeletal muscle use distinct glycogen pools, revealing compartmentalized glycogen metabolism.

Amino acid and nucleotide metabolism shape the selection of trophic levels in animals

The paper examines how amino acid and nucleotide metabolism influence trophic levels in animals by analyzing genome-scale metabolic models.

Analysis of Normal Levels of Urine and Plasma Free Glycosaminoglycans in Adults

This study establishes reference intervals for normal plasma and urine free glycosaminoglycans (GAGs) in healthy adults using UHPLC-MS/MS, revealing gender-based differences in GAG concentrations.

Analytical Performance of a Standardized Kit for Mass Spectrometry-based Measurements of Human Glycosaminoglycans

This study evaluates a UHPLC-MS/MS kit for standardized quantification of 17 GAG disaccharides, showing acceptable analytical performance in urine samples.

Proteome analysis of xylose metabolism in Rhodotorula toruloides during lipid production

This study analyzes the proteome of Rhodotorula toruloides during lipid production from xylose, identifying key metabolic differences compared to glucose.

Heart development in the lizards (Varanidae) with the greatest extent of ventricular septation

This paper studies heart development in monitor lizards, showing that their ventricular septa express conserved transcription factors and have functional similarities to mammalian septa.

Emergence of stable coexistence in a complex microbial community through metabolic cooperation and spatio-temporal niche partitioning

This study shows how kefir, a natural microbial community, achieves stable coexistence through spatio-temporal niche partitioning and metabolic cooperation during milk fermentation.

Investigation of putative regulatory acetylation sites in Fas2p of Saccharomyces cerevisiae

This study investigates the regulatory impact of acetylation sites on Fas2p in yeast by mutating lysine residues to glutamine or arginine and analyzing effects on fatty acid biosynthesis.

Engineering Lipid Droplet Assembly Mechanisms for Improved Triacylglycerols Accumulation in S. cerevisiae

This study improves triacylglycerol accumulation in S. cerevisiae by engineering lipid droplet assembly mechanisms, achieving up to 138% higher TAG levels without affecting growth or morphology.

Fundamental Constraints In Synchronous Muscle Limit Superfast Motor Control In Vertebrates

The paper identifies evolutionary and functional differences in superfast muscles across vertebrates, showing they evolved independently and are constrained by fundamental limits in synchronous muscle.