T. P. Burris

Distinct REV-ERBα Conformational State Predicted by GaMD Simulations Leads to the Structure-Based Discovery of Novel REV-ERBα Antagonist

This study uses GaMD simulations to identify a novel conformational state of REV-ERBα, enabling structure-based discovery of new antagonists.

REV-ERB Agonism Improves Liver Pathology in a Mouse Model of NASH

This study shows that activating REV-ERB with SR9009 improves liver health in a mouse NASH model by reducing fibrosis and inflammation.