Author

T. Perestrelo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:Drosophila· 1 Assay:imaging· 1

Frequent Co-Authors

A. Jimenez· 1 shared A. R. Pimenta-Marques· 1 shared B. Kim· 1 shared D. Wirtz· 1 shared I. Aifuwa· 1 shared J. M. Phillip· 1 shared K. Reddy· 1 shared M. Bettencourt-Dias· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Jimenez

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2 papers

Recent·Most cited

Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase

A. R. Pimenta-Marques, T. Perestrelo, P. Reis-Rodrigues, P. Duarte, M. Lince-Faria, M. Bettencourt-Dias

The paper identifies ANA1/CEP295 as essential for centriole structural integrity, showing its role in maintaining centrosome function through interactions with Polo kinase and PCM in Drosophila and cultured cells.

bioRxiv · Apr 6, 2022 · PreprintCell Biology

Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension

I. Aifuwa, J. M. Phillip, B. Kim, T. Luperchio, A. Jimenez, T. Perestrelo, S.-H. Lee, N. Longe, K. Reddy, T. Ha, D. Wirtz

This study shows senescent stroma reduces cancer cell nuclear tension via RhoA/ROCK/myosin II inhibition, leading to morphological changes linked to malignancy.

bioRxiv · Nov 17, 2021Cancer Biology