K. Reddy

Mutation of two intronic nucleotide alters RNA structure and dynamics, inhibiting MBNL1 and RBFOX1 regulated splicing of the Insulin Receptor

The paper shows that mutating two intronic nucleotides alters RNA structure and dynamics, disrupting MBNL1 and RBFOX1 regulation of INSR exon 11 splicing.

The unusual structural properties and potential biological relevance of switchback DNA

This study characterizes switchback DNA, a left-handed DNA structure, showing its unique stability, nuclease resistance, and potential biological role in tandem repeats.

Skeletons in the closet? Using a bibliometric lens to visualise phytochemical and pharmacological activities linked to Sceletium, a mood enhancer

This paper uses bibliometric analysis to identify research trends and gaps in the study of Sceletium's phytochemical and pharmacological activities.

Nucleoplasmic Lamin C Rapidly Accumulates at Sites of Nuclear Envelope Rupture with BAF and cGAS

The paper shows lamin C, BAF, and cGAS accumulate at nuclear envelope rupture sites in mouse cells, with lamin A/C involvement in DNA sensing.

Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension

This study shows senescent stroma reduces cancer cell nuclear tension via RhoA/ROCK/myosin II inhibition, leading to morphological changes linked to malignancy.

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics

This study shows that different nuclear lamin isoforms modulate cell and nuclear mechanics by affecting LINC complex stability and heterochromatin structure in mouse embryonic fibroblasts.

Lamin C regulates genome organization after mitosis

This study shows lamin C, not lamin A, is essential for post-mitotic 3D genome organization by regulating LADs' association with the nuclear envelope.