Glycolysis-enhancing alpha 1-adrenergic antagonists are neuroprotective in Alzheimers disease
Qiang Zhang, Jordan L. Schultz, Jacob E. Simmering, Braedon Q Kirkpatrick, Matthew A. Weber, Sydney Skuodas, T. Phillip Hicks, Grace Pierce, M. Harold Laughlin, Aimee X. Bertolli, Travis Larson, Ramasamy Thangavel, Mayu Oya, David Kyle Meyerholz, Georgina M. Aldridge, , Nandakumar S. Narayanan
This study shows that the alpha 1-adrenergic antagonist terazosin enhances glycolysis and is neuroprotective in Alzheimer's disease by reducing amyloid pathology and slowing cognitive decline.
bioRxiv · Apr 3, 2025 · PreprintNeuroscience