Georgina M. Aldridge

Neuronal ramping and theta power during freely-moving and head-fixed mouse interval timing.

This study shows that prefrontal neuronal ramping and theta activity occur during both freely-moving and head-fixed interval timing tasks in mice, suggesting they are features of temporal behavior rather than specific motor programs.

Renovating the Barnes maze for mouse models of Dementia with STARR FIELD: A 4-day protocol for learning rate, retention and cognitive flexibility.

Male mice are particularly vulnerable to cognitive impairment following mTBI

This study investigates cognitive impairments in male and female mice after mild TBI, finding sex-specific deficits in interval timing and novel object recognition.

Glycolysis-enhancing alpha 1-adrenergic antagonists are neuroprotective in Alzheimers disease

This study shows that the alpha 1-adrenergic antagonist terazosin enhances glycolysis and is neuroprotective in Alzheimer's disease by reducing amyloid pathology and slowing cognitive decline.

Tau pathology in the dorsal raphe may be a prodromal indicator of Alzheimer's disease

The paper identifies tau pathology in the dorsal raphe nucleus as a potential early indicator of Alzheimer's disease, linked to behavioral changes and neuroinflammation.

Enhanced spine stability and survival lead to increases in dendritic spine density as an early response to local alpha-synuclein overexpression in mouse prefrontal cortex

This study shows that local alpha-synuclein overexpression in mouse prefrontal cortex increases dendritic spine density and stability early on, without significant changes in total spine turnover.

Cortical alpha-synuclein preformed fibrils do not affect interval timing in mice

This study investigates whether cortical injection of alpha-synuclein preformed fibrils (PFF) affects interval timing in mice, finding no consistent deficits despite synucleinopathy.