Author

T. R. Dafforn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. C. W. Pike· 1 shared A. Evans· 1 shared A. S. Lavado· 1 shared A. Teodosio· 1 shared C. A. Brady· 1 shared C. Matas de las Heras· 1 shared C. Nasrallah· 1 shared C. Pallini· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

A. C. W. Pike

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Author profile →

2 papers

Recent·Most cited

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

H. Z. Li, A. C. W. Pike, G. Chi, J. S. Hansen, S. G. Lee, K. E. J. Rodstrom, S. R. Bushell, D. Speedman, A. Evans, D. Wang, D. He, L. Shrestha, C. Nasrallah, N. A. Burgess-Brown, T. R. Dafforn, , D. B. Sauer

The paper determines the structure of the SIT1 proline transporter complexed with ACE2 using cryo-EM, revealing substrate specificity and structural changes related to transport and a disease-causing mutation.

bioRxiv · May 17, 2023Biophysics

A cell-based, spike protein binding assay highlights differences in antibody neutralising capacity for SARS-CoV-2 variants

N. Harrison, L. Richardson, C. Pallini, I. Morano, E. Jinks, J. Cowley, H. Chan, H. Hill, C. Matas de las Heras, A. Teodosio, A. S. Lavado, T. R. Dafforn, D. K. Grammatopoulos, J. Gordon, C. A. Brady, , O. S. Qureshi

The paper develops a cell-based ACE2/spike protein binding assay to assess antibody neutralising capacity against SARS-CoV-2 variants and shows differential blocking activity of monoclonal antibodies.

bioRxiv · Jun 24, 2022 · PreprintCell Biology