Author

S. G. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:Arabidopsis· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. M. Jez· 3 shared B. N. Kunkel· 2 shared A. C. W. Pike· 1 shared A. Evans· 1 shared A. J. Jezewski· 1 shared A. R. Odom John· 1 shared B. A. Snow· 1 shared C. C. Stevenson· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersMicrobiology

J. M. Jez

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Investigating the biosynthesis and roles of the auxin phenylacetic acid during Pseudomonas syringae-Arabidopsis thaliana pathogenesis

C.-Y. Lee, C. P. Harper, S. G. Lee, Y. Qi, T. Clay, Y. Aoi, J. M. Jez, H. Kasahara, J. A. V. Blodgett, B. N. Kunkel

This study investigates the role of phenylacetic acid (PAA) produced by Pseudomonas syringae during infection of Arabidopsis thaliana, showing that PAA/IAA homeostasis affects plant-microbial interactions.

bioRxiv · Apr 4, 2024 · PreprintMicrobiology

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

H. Z. Li, A. C. W. Pike, G. Chi, J. S. Hansen, S. G. Lee, K. E. J. Rodstrom, S. R. Bushell, D. Speedman, A. Evans, D. Wang, D. He, L. Shrestha, C. Nasrallah, N. A. Burgess-Brown, T. R. Dafforn, , D. B. Sauer

The paper determines the structure of the SIT1 proline transporter complexed with ACE2 using cryo-EM, revealing substrate specificity and structural changes related to transport and a disease-causing mutation.

bioRxiv · May 17, 2023Biophysics

Surface glia predominantly contribute to the development of ALS/FTD in Drosophila model

B. A. Snow, C. C. Stevenson, J. Kaur, S. G. Lee, Y. Wei, H. Miao, W. J. Kim

The paper shows surface glia are key in C9orf72-mediated ALS/FTD in Drosophila using genetic tools to mark glial subtypes.

bioRxiv · Oct 7, 2022 · PreprintPathology

A simple strategy to reduce the salivary gland and kidney uptake of PSMA targeting small molecule radiopharmaceuticals

T. M. Kalidindi, S. G. Lee, K. Jou, G. Chakraborty, M. Skafida, S. T. Tagawa, N. H. Bander, H. Schoder, L. Bodei, N. Pandit-Taskar, J. S. Lewis, S. M. Larson, J. R. Osborne, N. Pillarsetty

This study shows adding cold PSMA-11 reduces salivary gland and kidney uptake of [177Lu]-PSMA-617 without affecting tumor uptake in mice.

bioRxiv · Jul 24, 2020Pharmacology & Toxicology

Potent, specific MEPicides for treatment of zoonotic staphylococci

R. L. Edwards, I. Heueck, S. G. Lee, I. T. Shah, A. J. Jezewski, J. J. Miller, M. O. Mikati, X. Wang, R. C. Brothers, K. M. Heidel, C.-A. D. Burnham, S. Alvarez, S. A. Fritz, C. S. Dowd, J. M. Jez, A. R. Odom John

This paper identifies DXR as a druggable target for zoonotic staphylococci and develops potent prodrug inhibitors (MEPicides) that bypass transporter requirements.

PLOS Pathogens · Jun 4, 2020Peer-reviewedMicrobiology

Indole-3-Acetaldehyde Dehydrogenase-dependent Auxin Synthesis Contributes to Virulence of Pseudomonas syringae Strain DC3000

S. A. McClerklin, S. G. Lee, R. Nwumeh, J. M. Jez, B. N. Kunkel

This paper identifies a novel pathway in Pseudomonas syringae for auxin synthesis via AldA, showing it enhances virulence by suppressing host defenses.

bioRxiv · Aug 8, 2017Microbiology