Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells
C. A. Berdan, R. Ho, H. S. Lehtola, M. To, X. Hu, T. R. Huffman, Y. Petri, C. R. Altobelli, S. G. Demeulenaere, J. A. Olzmann, T. J. Maimone, D. K. Nomura
This study identifies parthenolide's covalent targeting of FAK1 in breast cancer cells, showing inhibition of FAK1-dependent pathways and cancer cell proliferation.
bioRxiv · Feb 15, 2019Cancer Biology