J. A. Olzmann

Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis

This study identifies structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis, with FSEN1 showing potent on-target inhibition and synergy with ferroptosis inducers.

Selenium reduction of ubiquinone via SQOR suppresses ferroptosis

The paper shows selenium reduces ubiquinone to ubiquinol via SQOR, protecting against ferroptosis independently of selenoprotein production.

A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity

This study uses a CRISPR screen to identify genetic factors affecting cancer cell resistance to C6-ceramide, revealing a role for plasma membrane asymmetry in ceramide toxicity.

Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation

The paper uses CRISPR-Cas9 screens to identify genes regulating PLIN2 and lipid droplet abundance, revealing new mechanisms and creating a resource for lipid metabolism research.

VPS13A and VPS13C influence lipid droplet abundance

This study shows that loss of VPS13A or VPS13C reduces lipid droplet abundance in cells under oleate-stimulated conditions.

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

This study identifies nimbolide's mechanism of action by showing it targets RNF114, leading to stabilization of p21 and inhibition of breast cancer cell proliferation.

Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells

This study identifies parthenolide's covalent targeting of FAK1 in breast cancer cells, showing inhibition of FAK1-dependent pathways and cancer cell proliferation.