Author

T. R. Lyons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. L. Wyatt· 2 shared T. R. Rutherford· 2 shared A. Kaupinis· 1 shared A. M. Elder· 1 shared A. Nelson· 1 shared C. Young· 1 shared E. Duncan· 1 shared E. S. Linklater· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCancer Biology

G. L. Wyatt

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5 papers

Recent·Most cited

Anoikis resistance in mammary epithelial cells is mediated by semaphorin-7a.

T. R. Rutherford, A. M. Elder, T. R. Lyons

This study shows SEMA7A promotes anoikis resistance in mammary epithelial cells via integrins and AKT, and its absence reduces luminal progenitor cells during involution, suggesting a role in breast cancer recurrence.

bioRxiv · Jun 28, 2021Cell Biology

Rab40/Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration and invasion

E. S. Linklater, E. Duncan, K. J. Han, A. Kaupinis, M. Valius, T. R. Lyons, R. Prekeris

This study identifies Rab40b/Cullin5 complex as a regulator of EPLIN and actin cytoskeleton dynamics, affecting cell migration and invasion through focal adhesion and stress fiber changes.

bioRxiv · Apr 1, 2021Cell Biology

Hormonal regulation of Semaphorin 7a in ER+ breast cancer drives therapeutic resistance

L. S. Crump, G. L. Wyatt, T. R. Rutherford, J. K. Richer, W. W. Porter, T. R. Lyons

This study identifies SEMA7A as a driver of therapeutic resistance in ER+ breast cancer and suggests targeting survival signaling pathways as a potential treatment strategy.

bioRxiv · Oct 5, 2020Cancer Biology

Postpartum breast cancer progression is driven by semaphorin 7a mediated invasion and survival

S. Tarullo, R. Hill, K. Hansen, F. Behbod, V. F. Borges, A. Nelson, T. R. Lyons

This study shows SEMA7A drives postpartum breast cancer progression by enhancing invasion, survival, and tumor microenvironment changes, with potential therapeutic implications.

bioRxiv · Jan 23, 2020Cancer Biology

Cross-talk between SIM2s and NFkB regulates cyclooxygenase 2 expression in breast cancer

G. L. Wyatt, C. Young, L. Crump, V. Wessells, T. Gustafson, Y.-Y. Fan, R. Chapkin, W. Porter, T. R. Lyons

This study shows that SIM2s inhibits NFkB activation and COX-2 expression in breast cancer, suggesting a potential therapeutic target.

bioRxiv · May 10, 2019Cancer Biology