Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics
S. M. Braet, T. S. Buckley, V. Venkatakrishnan, K.-M. A. Dam, P. J. Bjorkman, G. S. Anand
The paper tracks changes in SARS-CoV-2 spike protein dynamics across variants using hydrogen/deuterium exchange mass spectrometry, revealing progressive stabilization of the trimer stalk and enhanced NTD dynamics in Omicron BA.1.
bioRxiv · Aug 26, 2022Biophysics