Author

K.-M. A. Dam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

P. J. Bjorkman· 5 shared H. B. Gristick· 3 shared Z. Yang· 3 shared M. A. Martin· 2 shared M. C. Nussenzweig· 2 shared W. Hubbell· 2 shared A. Escolano· 1 shared A. Gazumyan· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersImmunology

P. J. Bjorkman

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Author profile →

6 papers

Recent·Most cited

Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies

D. Parthasarathy, K. R. Pothula, K.-M. A. Dam, S. Ratnapriya, H. C. Benet, R. Parsons, X. Huang, S. Sammour, K. Janowska, M. Harris, S. Sacco, J. Sodroski, M. Bridges, W. Hubbell, P. Acharya, A. Herschhorn

This paper shows that some HIV-1 transmitted/founder Envs are incompletely closed, making them sensitive to antibodies targeting open conformations, and highlights the importance of Env conformational flexibility for bnAb neutralization.

bioRxiv · Sep 13, 2023Microbiology

CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals

H. B. Gristick, H. Hartweger, M. Loewe, J. van Schooten, V. Ramos, T. Y. Oliviera, Y. Nishimura, N. S. Koranda, A. Wall, K.-H. Yao, D. Poston, A. Gazumyan, M. Wiatr, M. Horning, J. R. Keeffe, , P. J. Bjorkman

This study shows that CD4bs immunogens can elicit potent, broad anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals.

bioRxiv · Sep 8, 2022Immunology

Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics

S. M. Braet, T. S. Buckley, V. Venkatakrishnan, K.-M. A. Dam, P. J. Bjorkman, G. S. Anand

The paper tracks changes in SARS-CoV-2 spike protein dynamics across variants using hydrogen/deuterium exchange mass spectrometry, revealing progressive stabilization of the trimer stalk and enhanced NTD dynamics in Omicron BA.1.

bioRxiv · Aug 26, 2022Biophysics

Antibody recognition of CD4-induced open HIV-1 Env trimers

Z. Yang, K.-M. A. Dam, J. M. Gershoni, S. Zolla-Pazner, P. J. Bjorkman

This paper characterizes monoclonal antibodies that recognize the CD4-induced open conformation of HIV-1 Env trimers and describes their structural interactions with Env and CD4.

bioRxiv · Jul 27, 2022Immunology

HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design

K.-M. A. Dam, C. O. Barnes, H. B. Gristick, T. Schoofs, M. C. Nussenzweig, P. J. Bjorkman

The paper uses cryo-EM to study germline antibody-Env structures to identify key interactions and guide vaccine design.

bioRxiv · Mar 25, 2022Biochemistry

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Z. Yang, K.-M. A. Dam, M. D. Bridges, M. A. G. Hoffmann, A. T. DeLaitsch, H. B. Gristick, A. Escolano, R. Gautam, M. A. Martin, M. Nussenzweig, W. Hubbell, P. J. Bjorkman

This study identifies two antibodies from immunized macaques that neutralize HIV-1 by targeting the CD4-binding site on an occluded-open Env trimer conformation.

bioRxiv · Nov 2, 2021Immunology