Author

T. S. Mills

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. M. Pietras· 2 shared G. Hernandez· 2 shared J. L. Rabe· 2 shared J. S. Chavez· 2 shared A. D'Alessandro· 1 shared A. Goodspeed· 1 shared B. Kain· 1 shared B. M. Idler· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

E. M. Pietras

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Hematopoietic stem cells are a long-term reservoir for trained immunity in a mouse model of chronic autoimmune disease

T. S. Mills, B. Kain, M. T. Burchill, E. Danis, A. Goodspeed, R. Culp-Hill, S. Ferrara, J. R. Roede, A. D'Alessandro, K. Y. King, E. M. Pietras

The paper shows hematopoietic stem cells (HSCs) in a mouse model of chronic autoimmune disease serve as a long-term reservoir for trained immunity, with macrophages derived from them exhibiting increased inflammatory activity and reduced metabolic function.

bioRxiv · May 20, 2022 · PreprintImmunology

PU.1 expression defines distinct functional activities in the phenotypic HSC compartment in a mouse model of inflammatory stress

J. S. Chavez, J. L. Rabe, G. Hernandez, T. S. Mills, K. E. Nino, P. Davizon-Castillo, E. Pietras

The paper shows that PU.1 expression levels in phenotypic HSCs define distinct functional activities under steady-state and inflammatory conditions.

bioRxiv · Oct 25, 2021 · PreprintCell Biology

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

J. S. Chavez, J. L. Rabe, D. Loeffler, K. Higa, G. Hernandez, T. S. Mills, N. Ahmed, R. L. Gessner, Z. Ke, B. M. Idler, H. M. Kim, J. R. Myers, B. M. Stevens, C. T. Jordan, H. Nakajima, , E. M. Pietras

This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.

Journal of Experimental Medicine · Apr 15, 2021Peer-reviewedImmunology