Author

D. Loeffler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Plant Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:Bayesian inference· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Assay:flow cytometry· 1

Frequent Co-Authors

T. Schroeder· 3 shared A. Holm· 2 shared C. McGuire· 2 shared C. P. Moehs· 2 shared J. van Boxtel· 2 shared N. Ahmed· 2 shared W. J. Austill· 2 shared A. J. Slade· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

T. Schroeder

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Heritable changes in division speed accompany the diversification of singleT cell fate

M. Plambeck, A. Kazeroonian, D. Loeffler, T. Schroeder, D. H. Busch, M. Flossdorf, V. R. Buchholz

This study tracks division speed and lineage fate in single CD8+ T cells during clonal expansion, revealing a burst phase of homogeneous division followed by diversification into effector and memory branches.

bioRxiv · Jul 28, 2021Immunology

Open-source personal pipetting robots with live-cell incubation and microscopy compatibility

P. Dettinger, T. Kull, G. Arekatla, N. Ahmed, Y. Zhang, F. Schneiter, A. Wehling, D. Schirmacher, S. Kawamura, D. Loeffler, T. Schroeder

The paper introduces an open-source personal pipetting robot compatible with live-cell incubation and microscopy, designed for non-specialists to automate experiments.

bioRxiv · Jul 4, 2021Bioengineering

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

J. S. Chavez, J. L. Rabe, D. Loeffler, K. Higa, G. Hernandez, T. S. Mills, N. Ahmed, R. L. Gessner, Z. Ke, B. M. Idler, H. M. Kim, J. R. Myers, B. M. Stevens, C. T. Jordan, H. Nakajima, , E. M. Pietras

This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.

Journal of Experimental Medicine · Apr 15, 2021Peer-reviewedImmunology

Development of non-transgenic glyphosate tolerant wheat by TILLING

C. P. Moehs, W. J. Austill, D. Facciotti, A. Holm, D. Loeffler, Z. Lu, J. C. Mullenberg, A. J. Slade, M. N. Steine, J. van Boxtel, C. McGuire

This study develops glyphosate-tolerant wheat using TILLING to combine T102I and P106S mutations in the EPSPS gene, resulting in substantial herbicide tolerance.

bioRxiv · Jul 23, 2020Plant Biology

Development of reduced gluten wheat enabled by determination of the genetic basis of the lys3a low hordein barley mutant

C. P. Moehs, W. J. Austill, A. Holm, T. A. G. Large, D. Loeffler, J. Mullenberg, P. S. Schnable, W. Skinner, J. van Boxtel, L. Wu, C. McGuire

The paper identifies a genetic mutation in barley that reduces prolamin content and uses it to develop reduced gluten wheat through targeted mutagenesis.

bioRxiv · Jun 23, 2018 · PreprintPlant Biology