Ribosome Profiling Reveals Translational Reprogramming via mTOR Activation in Omacetaxine Resistant Multiple Myeloma
Z. J. Walker, K. F. Vaeth, A. Baldwin, D. J. Ohlstrom, L. T. Reiman, B. M. Idler, B. M. Stevens, N. Mukherjee, D. W. Sherbenou
This study identifies translational reprogramming via mTOR activation as a mechanism of omacetaxine resistance in multiple myeloma and suggests combination therapy with mTOR inhibitors.
bioRxiv · Apr 23, 2024Cancer Biology