Author

T. S. Worgall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Bretin· 1 shared A. F. Cowman· 1 shared A. L. Cheung· 1 shared A. L. Goodman· 1 shared A. T. Gewirtz· 1 shared B. I. Kim· 1 shared B. Y. Zou· 1 shared C. Tapia-Alveal· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperMicrobiology

A. Bretin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Effect of Total Sphingomyelin Synthase Activity on Low Density Lipoprotein Catabolism in Mice

X.-C. Jiang, Z. Li, M. He, T. S. Worgall, G. Chen

This study shows that total sphingomyelin synthase (SMS) deficiency reduces LDL receptors and impairs LDL catabolism in mice, while SMS2 deficiency does not have this effect.

bioRxiv · Feb 3, 2023 · PreprintBiochemistry

Microfluidic Isolation of Aptamers with Affinity towards Multiple Myeloma Monoclonal Immunoglobulins (M-Ig)

T. R. Olsen, C. Tapia-Alveal, M. N. Stojanovic, T. S. Worgall, Q. Lin

This paper develops a microfluidic method to rapidly generate patient-specific aptamers that bind multiple myeloma monoclonal immunoglobulins with high affinity.

bioRxiv · Sep 22, 2020 · PreprintBioengineering

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

G. M. LaMonte, D. S. Marapana, N. Gnadig, S. Ottilie, M. R. Luth, T. S. Worgall, F. Rocamora, G. M. Goldgof, R. Mohunlal, T. R. S. Kumar, J. K. Thompson, E. Vigil, J. Yang, D. Hutson, T. Johnson, , E. A. Winzeler

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

bioRxiv · Aug 15, 2019Microbiology

Sphingolipid production by gut Bacteroidetes regulates glucose homeostasis

E. L. Johnson, S. L. Heaver, J. L. Waters, B. I. Kim, A. Bretin, A. L. Goodman, A. T. Gewirtz, T. S. Worgall, R. E. Ley

This study shows gut Bacteroidetes produce sphingolipids that affect liver ceramide levels and insulin sensitivity.

bioRxiv · May 9, 2019 · PreprintMicrobiology