A. T. Gewirtz

The paper shows that segmented filamentous bacteria reprogram alveolar macrophages to enhance non-inflammatory defense against respiratory viruses.

This study shows psyllium fiber protects mice from diet-induced metabolic syndrome via microbiota-dependent mechanisms, with higher doses acting FXR-independently.

The paper identifies a novel mechanism of TLR5 interaction with flagellins from gut commensal bacteria, termed silent recognition, which explains weak immune responses despite strong binding.

This study identifies SMYD5 as a driver of IBD by downregulating mitochondrial functions through methylation-dependent degradation of PGC-1α in intestinal epithelial cells.

This study shows that a western-style diet impairs gut microbiota's ability to clear bacterial pathogens, leading to chronic inflammation and insulin resistance.

This study identifies a Listeria bacteriocin that specifically targets Prevotella copri, showing microbiota-dependent effects on Listeria infection in mice.

This study shows gut Bacteroidetes produce sphingolipids that affect liver ceramide levels and insulin sensitivity.

This study shows TLR5 signaling in epithelial cells affects B cell populations and antibody responses, leading to microbiome dysbiosis in TLR5-deficient mice.