T. Schiex

Designing symmetrical multi-component proteins using a hybrid generative AI approach

This paper introduces a hybrid generative AI approach to design multi-component proteins by combining deep learning and automated reasoning, showing improved performance over existing methods in creating heteromeric assemblies.

Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular S. Typhimurium

This paper compares the intracellular transcriptomic profiles and phenotypes of Salmonella Paratyphi A and Salmonella Typhimurium during epithelial cell infection, identifying differences in flagella-chemotaxis, SPI-1, and carbon utilization pathways, and showing cytosolic motility and increased invasiveness of SPA.

Seven amino acid types suffice to reconstruct the core fold of RNA polymerase

The paper reconstructs the DPBB fold using only seven amino acid types, suggesting it could have emerged with the early genetic code.