E. Cohen

Pesticide chemical leads inhibiting protein-protein interactions

This study identifies small molecule inhibitors targeting the PPI complex of OASS and SAT, offering a new mode of action for herbicides.

Vole genomics links determinate and indeterminate growth of teeth

This study identifies dental genes under positive selection in voles with different molar root structures, linking genetic changes to tooth growth patterns.

Stable long-term individual variation in chimpanzee technological efficiency

This study investigates long-term individual variation in chimpanzee nut-cracking efficiency over 25 years, finding stable differences that challenge previous sex-based conclusions.

Keratin 17- and PKCα-dependent transient amplification of neutrophil influx after repeated stress to the skin

The paper identifies a keratin 17- and PKCα-dependent mechanism that transiently amplifies neutrophil influx in stressed skin, revealing a novel pathway in chronic inflammatory skin diseases.

Alterations of the TGFb-sequestration complex member ADAMTSL1 levels are associated with muscular defects and rhabdomyosarcoma aggressiveness

This study shows ADAMTSL1 is involved in skeletal muscle regeneration and acts as a prognostic factor in aggressive rhabdomyosarcoma, correlating with a neural-like phenotype.

Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular S. Typhimurium

This paper compares the intracellular transcriptomic profiles and phenotypes of Salmonella Paratyphi A and Salmonella Typhimurium during epithelial cell infection, identifying differences in flagella-chemotaxis, SPI-1, and carbon utilization pathways, and showing cytosolic motility and increased invasiveness of SPA.

Full-length native CGRP neuropeptide and its stable analogue SAX, but not CGRP peptide fragments, inhibit mucosal HIV-1 transmission

The paper shows that full-length CGRP and its analogue SAX inhibit HIV-1 transmission via Langerhans cells, while fragments do not, and CGRP enters mucosal tissues without altering immune cell distribution.

Capsaicin activates TRPV1 in human Langerhans cells and inhibits mucosal HIV-1 transmission via secreted CGRP

This study shows that TRPV1 activation in Langerhans cells increases CGRP secretion, which inhibits HIV-1 trans-infection, suggesting TRPV1 agonists could be used as topical microbicides.

Temporal Requirements of SKN-1/NRF as a Regulator of Lifespan and Proteostasis in Caenorhabditis elegans

This study identifies the temporal role of SKN-1 in regulating lifespan and proteostasis in C. elegans, showing its importance during late larval development through early adulthood.

Gene Expression Modulation by the Linker of Nucleoskeleton and Cytoskeleton Complex Contributes to Proteostasis

This study shows that the LINC complex modulates proteostasis by affecting ubiquitination and degradation rates in nematodes, linking it to aging-associated proteotoxicity.

A Cell Cycle Switch Dictates Organ Repair and Tissue Growth Responses in The Drosophila Hindgut

The paper shows that in Drosophila hindgut, larval cells undergo mitosis while adult cells undergo endocycles after injury, with endocycles preserving epithelial architecture under sustained growth signals.

A hidden Markov model approach to characterizing the photo-switching behavior of fluorophores

The paper uses a hidden Markov model to characterize fluorophore photo-switching behavior by estimating transition rates from image sequences.