Author

T. Sebastian

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

C. R. Fraire· 1 shared J. Lee· 1 shared K. Desai· 1 shared K. Onel· 1 shared K. S. Chen· 1 shared L. K. Mendyka· 1 shared S. X. Skapek· 1 shared U. A. Obalapuram· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

C. R. Fraire

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1 paper

Recent·Most cited

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

C. R. Fraire, K. Desai, U. A. Obalapuram, L. K. Mendyka, V. Rajaram, T. Sebastian, Y. Wang, K. Onel, J. Lee, S. X. Skapek, K. S. Chen

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.

bioRxiv · Apr 23, 2024Cancer Biology