K. Desai

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.

Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.

Comprehensive genome editing confers "off-the-shelf" CAR-T cells superior efficacy against solid tumors

The paper develops genome-edited CAR-T cells resistant to multiple inhibitory signals, showing improved efficacy against solid tumors in humanized mouse models.

Context-specific GITR agonism potentiates anti-PD-L1 and CD40-based immuno- chemotherapy combination in heterogeneous pancreatic tumors

This study identifies GITR agonism as a potential enhancer of anti-PD-L1 and CD40-based immunotherapy in pancreatic tumors by targeting immune evasion mechanisms.

A comprehensive analysis of immune landscape of Indian triple negative breast cancer

This study identifies three immune subtypes in Indian triple-negative breast cancer patients, showing similarities to Western TNBCs and potential for immunotherapy response.

Consistent measurement of LAG-3 expression across multiple staining platforms with the 17B4 antibody clone

This study evaluates the consistency of LAG-3 IHC assays using the 17B4 antibody across three staining platforms, finding high correlation and agreement.

SerpinB3 drives cancer stem cell survival in glioblastoma

This study identifies SerpinB3 as a key driver of glioblastoma cancer stem cell survival and shows that targeting it enhances radiation therapy efficacy in pre-clinical models.