Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells
K. E. Clements, T. Thakar, C. M. Nicolae, X. Liang, H.-G. Wang, G.-L. Moldovan
This study identifies E2F7 as a regulator of chemoresistance in BRCA2-deficient cells, showing its role in enhancing PARP inhibitor and cisplatin resistance through RAD51 upregulation.
bioRxiv · Apr 3, 2018Cancer Biology