Disruption of Z-RNA-binding of ADAR1 induces Aicardi-Goutieres syndrome-like encephalopathy in mice
T. Nakahama, Y. Kato, T. Shibuya, J. I. Kim, T. Vongpipatana, H. Todo, Y. Xing, Y. Kawahara
This study shows that disrupting ADAR1 p150's Z-RNA-binding domain in mice causes AGS-like encephalopathy with type I IFN signature, which is alleviated by MDA5 deletion.
bioRxiv · Dec 16, 2020 · PreprintImmunology