Y. Xing

Unveiling the PHR-centered regulatory network orchestrating the phosphate starvation signaling in Chinese fir (Cunninghamia lanceolata)

This study identifies ClPHRs as key regulators of phosphate starvation signaling in Chinese fir, revealing evolutionary differences in the SPX-PHR module compared to model plants.

Machine Learning Models for Cardiovascular Disease Prediction: A Comparative Study

This study compares KNN, logistic regression, and random forest for predicting cardiovascular disease using a Kaggle dataset, finding random forest to be the most accurate.

Distinct effects of CDK8 module subunits on cellular growth and proliferation in Drosophila

This study investigates the distinct roles of CDK8 module subunits in Drosophila, showing that Med12-Med13 disruption severely impacts ribosome biogenesis and growth, while CDK8-CycC affects cell-cycle progression.

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Extracellular vesicles-based point-of-care testing for the diagnosis and monitoring of Alzheimer's disease

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

Translating Ethiopian potato seed networks: Identifying strategic intervention points for managing bacterial wilt and other diseases

This study identifies key locations and strategies to manage bacterial wilt spread in Ethiopia's potato seed systems through network analysis and risk assessment.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

The Mechanism Insight into Bacterial Degradation of Pentachlorobiphenyl

This study identifies a new bacterium capable of degrading pentachlorobiphenyl and characterizes its enzymatic, proteomic, and metabolomic responses to the pollutant.

Electron-bifurcation and fluoride efflux systems in Acetobacterium spp. drive defluorination of perfluorinated unsaturated carboxylic acids

This study identifies electron-bifurcation and fluoride efflux systems in Acetobacterium spp. that enable reductive defluorination of PFAS, supported by biochemical and structural evidence.

DNA Origami Lipid Membrane Interactions Defined at Single-Molecular Resolution

The paper investigates DNA nanostructure interactions with lipid membranes using single-molecule techniques, revealing how anchor placement and membrane curvature influence binding.

Injury induced renal fibrosis promotes cystogenesis and cyst growth in adult mice with autosomal dominant polycystic kidney disease

This study shows that renal fibrosis induced by injury promotes cyst formation and growth in adult ADPKD mice, and targeting EZH2 can reduce fibrosis and cyst growth.

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

This study shows miR-574-5p activates TLR8 to drive autoimmune signaling and lupus progression by enhancing cytokine production, STAT1 activation, and autoantigen generation.

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

Progress toward the development of an effective vaccine for Extraintestinal pathogenic E. coli (ExPEC): The application of the multiple-protein subunits vaccine in different murine models

This study evaluates pro-HlyA and Dual-Hit as vaccine candidates against ExPEC, showing reduced bacterial burden and increased survival in murine models.

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

The paper investigates the structural and functional dynamics of the PP2A-B56δ holoenzyme, showing how mutations linked to intellectual disability affect its allosteric network and phosphorylation rates.

Single-Cell Map of Dynamic Multicellular Ecosystem of Radiation-Induced Intestinal Injury

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

Sequential restoring O2 then unloading CO2 is beneficial against reperfusion injury: role of CO2 in metabolism

The paper shows that sequential reperfusion with high CO2 then normal CO2 reduces cardiac ischemic reperfusion injury in rat hearts by altering metabolic pathways.

An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments

The paper shows that flagellin outer domains and their inter-domain interactions are essential for motility in viscous environments in Pseudomonas aeruginosa.

Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

This study shows PME-1 demethylates PP2A holoenzymes and inhibits substrate recognition through structural interactions with the B56 subunit, revealing mechanisms of PME-1 activity and its role in p53 signaling.

A comprehensive analysis of Usutu virus (USUV) genomes revealed lineage-specific codon usage patterns and host adaptation

This study analyzes Usutu virus genomes to identify lineage-specific codon usage patterns and host adaptation mechanisms.

Transcriptome analysis of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine

The paper analyzes the transcriptome of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine to understand immune response mechanisms and vaccine effectiveness.

Specific phenotypic, genomic, and fitness evolutionary trajectories toward antibiotic resistance induced by pesticide co-stressors in Escherichia coli

This study shows that co-exposure to pesticides and streptomycin in E. coli leads to stronger antibiotic resistance with lower fitness costs and persistence after selective pressure removal.

Unbiased clade age estimation using a Bayesian Brownian Bridge

The paper defends the Bayesian Brownian Bridge method against criticism, showing its estimates of angiosperm clade ages are valid despite concerns about fossil data scarcity and sampling bias.

Intrinsic cardiac adrenergic cells contribute to septic cardiomyopathy

This study identifies intrinsic cardiac adrenergic cells as contributors to septic cardiomyopathy by releasing norepinephrine that exacerbates cardiac dysfunction through β1-adrenergic receptor activation.

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

Disruption of Z-RNA-binding of ADAR1 induces Aicardi-Goutieres syndrome-like encephalopathy in mice

This study shows that disrupting ADAR1 p150's Z-RNA-binding domain in mice causes AGS-like encephalopathy with type I IFN signature, which is alleviated by MDA5 deletion.

Repetitive and Brief Occlusion of the Majority of the Vena Cava Flow Attenuates Pulmonary Arterial Hypertension and Improves IK+ of the Pulmonary Arterial Smooth Muscle Cells in Rat Models: a novel potential therapeutic strategy for PAH

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion.

This study identifies the N-terminus of VZV glycoprotein B as critical for membrane fusion, showing that mutations in this region impair viral propagation.

Management performance mapping and the value of information for regional prioritization of management interventions

The paper develops a framework to map management performance and assess the value of information for targeting agricultural interventions in Andean and Kenyan potato seed systems.

Glucose Production and Glucose Disposal Integrated by an Intrinsic Inverse Coupling in Vivo: hypothesis of inter-organ reflex on glucose regulation

The paper demonstrates that glucose production and disposal are inversely coupled in vivo, regardless of insulin target site, and shows this coupling persists despite metabolic challenges.