Impaired hematopoiesis and leukemia development in mice with a conditional \"knock-in\" allele of a mutant splicing factor gene U2af1
D. L. Fei, T. Zhen, B. Durham, J. Ferrarone, T. Zhang, L. Garrett, A. Yoshimi, O. Abdel-Wahab, R. Bradley, P. Liu, H. Varmus
This paper generates a mouse model with a conditional knock-in of the U2af1(S34F) mutation to study its role in hematopoiesis and leukemia, finding that it requires additional mutations for leukemogenesis.
bioRxiv · Jul 26, 2018Cancer Biology