Author

D. L. Fei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Heard· 1 shared A. Khanna· 1 shared A. Yoshimi· 1 shared B. A. Wadugu· 1 shared B. Durham· 1 shared C. A. Miller· 1 shared C. L. Shirai· 1 shared H. Varmus· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Heard

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Author profile →

2 papers

Recent·Most cited

U2AF1 is a haplo-essential gene required for cancer cell survival

B. A. Wadugu, A. Heard, S. N. Srivatsan, M. O. Alberti, M. Ndonwi, J. Bradley, J. Shao, T. Ahmed, C. L. Shirai, A. Khanna, D. L. Fei, C. A. Miller, T. A. Graubert, M. J. Walter

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

Journal of Clinical Investigation · Nov 1, 2021Peer-reviewedCancer Biology

Impaired hematopoiesis and leukemia development in mice with a conditional \"knock-in\" allele of a mutant splicing factor gene U2af1

D. L. Fei, T. Zhen, B. Durham, J. Ferrarone, T. Zhang, L. Garrett, A. Yoshimi, O. Abdel-Wahab, R. Bradley, P. Liu, H. Varmus

This paper generates a mouse model with a conditional knock-in of the U2af1(S34F) mutation to study its role in hematopoiesis and leukemia, finding that it requires additional mutations for leukemogenesis.

bioRxiv · Jul 26, 2018Cancer Biology