Author

J. Ferrarone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

H. Varmus· 3 shared A. Liu· 1 shared A. Montalbano· 1 shared A. Nagelberg· 1 shared A. Unni· 1 shared A. Yoshimi· 1 shared B. Durham· 1 shared C. Brandstadter· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

H. Varmus

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3 papers

Recent·Most cited

LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase

J. Ferrarone, J. Thomas, A. Unni, Y. Zheng, M. Nagiec, E. Gardner, O. Mashadova, K. Li, N. Koundouros, A. Montalbano, M. Mustafa, L. Cantley, J. Blenis, N. Sanjana, H. Varmus

This study identifies LKB1's role in suppressing growth by activating PIKFYVE to promote EGFR internalization in LUAD.

bioRxiv · Oct 19, 2023 · PreprintCancer Biology

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

F. D. Johnson, J. Ferrarone, A. Liu, C. Brandstadter, R. Munuganti, D. Fansworth, D. Lu, J. Luu, T. Sihota, S. Jansen, A. Nagelberg, R. Shi, G. C. Forcina, X. Zhang, G. S. W. Cheng, , W. W. Lockwood

The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.

bioRxiv · Jun 28, 2021 · PreprintCancer Biology

Impaired hematopoiesis and leukemia development in mice with a conditional \"knock-in\" allele of a mutant splicing factor gene U2af1

D. L. Fei, T. Zhen, B. Durham, J. Ferrarone, T. Zhang, L. Garrett, A. Yoshimi, O. Abdel-Wahab, R. Bradley, P. Liu, H. Varmus

This paper generates a mouse model with a conditional knock-in of the U2af1(S34F) mutation to study its role in hematopoiesis and leukemia, finding that it requires additional mutations for leukemogenesis.

bioRxiv · Jul 26, 2018Cancer Biology