Author

T.-H. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Organism:human· 1 Organism:rat· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

M. Aleckovic· 2 shared S. Srinivasan· 2 shared A. Mahmoodi· 1 shared B. Zhang· 1 shared C. S. Boddupalli· 1 shared E. Teeple· 1 shared G. Belinsky· 1 shared G. Coricor· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

M. Aleckovic

Mutual co-authors in cluster

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3 papers

Recent·Most cited

SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species

S. Srinivasan, N. A. Yee, M. Zakharian, M. Aleckovic, A. Mahmoodi, T.-H. Nguyen, J. M. Mejia Oneto

This paper demonstrates SQ3370, a click chemistry-activated cancer therapeutic, is safe in humans and shows translatability across species with effective tumor activation and immune response.

bioRxiv · Mar 28, 2023 · PreprintPharmacology & Toxicology

Click chemistry selectively activates an auristatin protodrug with either intratumoral or systemic tumor-targeting agents

J. M. McFarland, M. Aleckovic, G. Coricor, S. Srinivasan, M. Tso, J. Lee, T.-H. Nguyen, J. M. M. Oneto

This paper demonstrates the activation of a protodrug, SQP22, using click chemistry with tumor-targeting agents, showing anti-tumor effects in murine models with reduced toxicity.

bioRxiv · Mar 28, 2023Pharmacology & Toxicology

Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells

P. Mistry, C. S. Boddupalli, G. Belinsky, J. Gans, E. Teeple, T.-H. Nguyen, S. Mehta, L. Guo, M. Kramer, J. Ruan, H. Wang, M. Davison, V. DJ, B. Zhang, K. Klinger, S. Nair

This study investigates neuroinflammation in neuronopathic Gaucher disease by examining microglia and NK cells in mouse models, showing that Gba rescue in these cells reduces neuroinflammation and improves survival.

bioRxiv · May 13, 2022Immunology