Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems
Ivana Yoseli Quiroga, A. Eden Cruikshank, Kathleen S Metz Reed, Marielle L. Bond, Baggio Evangelista, Jui‐Heng Tseng, Joey V. Ragusa, Rick B. Meeker, Hyejung Won, Sarah Cohen, T.J. Cohen, Douglas H. Phanstiel
The paper assesses the transcriptional response of in vitro innate immune cell models to synthetic amyloid beta and finds no robust response, but identifies LPS and INFγ as better activators of microglia-like cells.
Journal of Neuroinflammation · Apr 23, 2022Peer-reviewedNeuroscience