Baggio Evangelista

High-Content Screening Identifies Dithiocarbamates As A Class Of Chemicals That Disrupts TDP-43 Proteostasis

This study identifies dithiocarbamates as chemicals that disrupt TDP-43 proteostasis by causing aggregation and loss of function through redox imbalance and zinc homeostasis disruption.

MICRON learns outcome-associated representations of spatial immune microenvironments

MICRON identifies outcome-linked immune microenvironments from spatial imaging proteomics data, improving prognostic and diagnostic prediction in brain cancer.

Peripheral immune patterns enable robust cross-platform prediction of ALS onset and progression

The paper identifies immune coordination patterns in ALS patients and develops machine learning models to predict disease onset and progression using mass cytometry data.

Gigaxonin, mutated in Giant Axonal Neuropathy, interacts with TDP-43 and other RNA binding proteins

This study identifies RNA-binding protein interactions of gigaxonin, a protein mutated in Giant Axonal Neuropathy, revealing potential mechanisms linking its dysfunction to neurodegeneration.

Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems

The paper assesses the transcriptional response of in vitro innate immune cell models to synthetic amyloid beta and finds no robust response, but identifies LPS and INFγ as better activators of microglia-like cells.