Marielle L. Bond

KMT2C and KMT2D regulate skeletal development through stage-specific epigenetic control of chondrogenesis

This study shows that KMT2C and KMT2D regulate skeletal development through epigenetic control of chondrogenesis, with redundancy in their function during bone formation.

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

The paper identifies OA risk genes by integrating eQTLs, chromatin accessibility, and 3D chromatin structure in human chondrocytes, revealing 13 putative risk genes, 10 of which are novel.

Deciphering the functional impact of Alzheimers Disease-associated variants in resting and proinflammatory immune cells

The paper identifies 47 expression-modulating variants in AD-associated loci by analyzing their impact in immune cells under different inflammatory conditions.

Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants

The paper uses MPRA to identify functional regulatory variants associated with schizophrenia and shows they differ from eQTLs in genomic location and regulatory impact.

Chromatin loop dynamics during cellular differentiation are associated with changes to both anchor and internal regulatory features

The paper identifies differential chromatin loops during megakaryocyte differentiation and shows their association with gene expression changes and histone modifications.

WNT activity reveals context-specific genetic effects on gene regulation in neural progenitors

The paper identifies context-specific genetic effects on gene regulation in neural progenitors by stimulating the Wnt pathway and analyzing chromatin accessibility and gene expression.

Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription

The paper analyzes temporal changes in chromatin structure and gene expression during macrophage activation, finding a reciprocal relationship between loops and transcription.

Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems

The paper assesses the transcriptional response of in vitro innate immune cell models to synthetic amyloid beta and finds no robust response, but identifies LPS and INFγ as better activators of microglia-like cells.

CoralP: Flexible visualization of the human phosphatome

CoralP provides an interactive web tool for visualizing human phosphatome data with customizable attributes, offering a unique resource for phosphatase analysis.