Ivana Yoseli Quiroga

Hyperosmotic stress induces rewiring of 3D chromatin interactions

One hour of 200 mM sorbitol collapses most chromatin loops in human cells while several hundred transient, cohesin-dependent, CTCF-independent loops form at active promoters, preceding anchor-gene activation.

Aberrant chromatin looping by NUP98-HOXA9 is constrained by CTCF and facilitated by cohesin

This study investigates how NUP98-HOXA9 drives aberrant chromatin looping in AML by interacting with CTCF and cohesin, revealing a non-canonical mechanism involving phase separation and loop extrusion.

Deciphering the functional impact of Alzheimers Disease-associated variants in resting and proinflammatory immune cells

The paper identifies 47 expression-modulating variants in AD-associated loci by analyzing their impact in immune cells under different inflammatory conditions.

Chromatin loop dynamics during cellular differentiation are associated with changes to both anchor and internal regulatory features

The paper identifies differential chromatin loops during megakaryocyte differentiation and shows their association with gene expression changes and histone modifications.

First GWAS on Alzheimer's Disease in Argentina and Chile populations

This study conducts the first GWAS on Alzheimer's disease in South American populations, identifying shared genetic risk factors with European populations.

Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription

The paper analyzes temporal changes in chromatin structure and gene expression during macrophage activation, finding a reciprocal relationship between loops and transcription.

Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems

The paper assesses the transcriptional response of in vitro innate immune cell models to synthetic amyloid beta and finds no robust response, but identifies LPS and INFγ as better activators of microglia-like cells.