An Antibody Cocktail-Based Immunoaffinity-LC-MS Method Enabled Ultra-Sensitive and Robust Quantification of Circulating Proinsulin Proteoforms and C-peptide
Qingqing Shen, Wang Cao, Ming Zhang, Tai-Tu Lin, Gabriela S. F. Monaco, Lorenz A. Nierves, Tujin Shi, Cornelia L. Boeser, Scott M. Peterman, Carmella Evans‐Molina, Emily Kristen Sims, Weijun Qian, Jun Qu
This paper develops a sensitive LC-MS method to quantify circulating proinsulin proteoforms and C-peptide, showing improved separation of control and T1D groups compared to ELISA.
Analytical Chemistry · Aug 28, 2025Peer-reviewedBiochemistry