Weijun Qian

This study investigates how cyanophage CP12 modulates host carbon regulation by remodeling interfaces and buffering redox changes during infection.

The paper develops a 4D whole-cell model of Prochlorococcus marinus MED4 to show how spatial organization and redox PTMs regulate carbon fixation under light disturbance.

This paper uses integrated PTM proteomics to show that Ref-1 inhibition rapidly remodels redox and mitochondrial signaling in pancreatic cancer cells.

This study identifies transcriptional impairments in mitochondrial and protein homeostasis pathways in islets during type 1 diabetes pathogenesis, independent of T-cell infiltration.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

ProteoMeter integrates multi-PTM and limited proteolysis data to map proteomic changes to residue level, demonstrating its use in analyzing HCoV-229E infection.

The paper identifies carbamylation as a regulatory modification in β-cell metabolism and insulin processing in T1D by analyzing proteomic changes in NOD and MIN6 cells.

This paper identifies conserved transcriptional modules in Prochlorococcus MED4 using RNA-seq data and independent component analysis, revealing core regulatory programs that persist despite extreme genome reduction.

The paper integrates AMGs and phage assembly into a genome-scale metabolic model to predict their impact on host metabolism and phage production, revealing synergistic and antagonistic effects.

This study shows that activating AMPK alpha2 T172 in skeletal muscle improves exercise performance and energy transduction, and its disruption mimics type 2 diabetes features.

The paper uses single-islet proteomics to analyze pseudo-temporal immune responses and beta-cell dysfunction in stage 1 T1D, identifying key pathways involved in islet dysfunction.

This paper uses top-down proteomics to analyze changes in proteoforms of human pancreatic islets after cytokine treatment, identifying potential markers for T1D progression.

This paper develops a sensitive LC-MS method to quantify circulating proinsulin proteoforms and C-peptide, showing improved separation of control and T1D groups compared to ELISA.

The paper decodes the regulatory architecture of Synechococcus elongatus PCC 7942 under oxidative stress, revealing modular responses that balance growth and defense.

Laser-microdissected islets of 3 multiple-autoantibody-positive stage 1 type 1 diabetes donors versus matched controls show 202 altered proteins: immune and glycolytic up, translation and ER-stress proteins down.

The paper introduces nanoSPLITS, a platform for simultaneous transcriptome and proteome profiling of single cells, and demonstrates its application in cell cycle regulation and cell type identification.

This study benchmarks label-free and TMT-MS2 methods for spatial proteome mapping, showing label-free provides deeper coverage and higher dynamic range, while TMT-MS2 offers faster throughput.

This paper introduces a fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis, demonstrating its utility in identifying EV proteins related to physical activity.

This study shows that m6A methylation, regulated by METTL3, controls the innate immune response in β-cells during T1D onset by modulating OAS mRNA stability.

The paper generates a deep phosphoproteomics dataset of the EGFR-MAPK pathway in MCF10A cells and integrates it with protein databases to study kinase signaling.

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

The paper constructs a comprehensive urine proteome database from diverse renal and prostate cancer conditions, identifying potential biomarkers and unique proteins.