Author

Lorenz A. Nierves

Pacific Northwest National LaboratoryORCID 0000-0001-5545-4323Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Weijun QianiD· 3 shared Rohit N. KulkarniiD· 2 shared Tyler J. SagendorfiD· 2 shared Aizhong Fu· 1 shared Aly KarsaniD· 1 shared Ashley N. IvesiD· 1 shared Carmella Evans‐MolinaiD· 1 shared Clayton E. MathewsiD· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

Weijun QianORCID

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4 papers

Recent·Most cited

Systems BiologybioRxivPreprintNov 10, 2025

Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes

Shane S. Kelly, Soumyadeep Sarkar, Sarai M. Williams…·Weijun Qian

The paper uses single-islet proteomics to analyze pseudo-temporal immune responses and beta-cell dysfunction in stage 1 T1D, identifying key pathways involved in islet dysfunction.

1 citation

humanproteomics

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BiochemistryPROTEOMICSPeer-reviewedSep 21, 2025

Characterization of cytokine treatment on human pancreatic islets by top-down proteomics

Ashley N. Ives, Tyler J. Sagendorf, Lorenz A. Nierves…·James M. Fulcher

This paper uses top-down proteomics to analyze changes in proteoforms of human pancreatic islets after cytokine treatment, identifying potential markers for T1D progression.

4 citations

humanproteomics

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BiochemistryAnalytical ChemistryPeer-reviewedAug 28, 2025

An Antibody Cocktail-Based Immunoaffinity-LC-MS Method Enabled Ultra-Sensitive and Robust Quantification of Circulating Proinsulin Proteoforms and C-peptide

Qingqing Shen, Wang Cao, Ming Zhang…·Jun Qu

This paper develops a sensitive LC-MS method to quantify circulating proinsulin proteoforms and C-peptide, showing improved separation of control and T1D groups compared to ELISA.

5 citations

humanproteomics

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Cell BiologybioRxivPreprintFeb 28, 2024

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

Cristen M. Molzahn, Erich R. Kuechler, Lorenz A. Nierves…·Thibault Mayor

The paper analyzes protein levels and solubility in brain regions of aged mice, revealing age-related changes in proteostasis and inflammation markers.

DOI 10.1101/2024.02.28.582597

mouseproteomics

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